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Title   인체 위장관 종양세포주에 대한 재조합 감마 인테페론의 면역학적 효과 ( Immunologic Effects of Recombinant Gamma - interferon on Human Gastrointestinal Tumor Cell Lines )
Publicationinfo   1991 Jan; 023(01): 10-29.
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Abstract   Gamma-interferon, originally identified by its antiviral property, has been reported to inhibit tumor cell proliferation, augment natural killer cell and antibody dependent cytotoxic cell activities, enhace HLA antigen expression on tumor and lymphoid cell membranes, and activate macrophage. The present study was undertaken to investigate the biologic effects of gamma-interferon on the gastro- intestinal tumor cell lines that have been established in Seoul National University. Recombinant gamma-interferon has given antiproliferative effect and increaaed expression on MHC class I antigen on the gastrointestinal tumor cell lines. The cell line that exhibits the most prominent antiproliferative effects expresses laminin gene which has been detected by Northern blotting. The supernatant of monocytes also has prominent antiproliferative effect on the gastro- intestinal tumor cell lines. It is our idea that this substance seems to be novel cytokine because of functional activity totally different from known cytokine such as IL-I, IL-2, TNF and GM-CSF ect. Newly observed effect of gamma-interferon in the present study was inverse relationship between of MHC class I expression and natural killer cytotoxicity. In conclusion, the gamma-interferon can be therapeutic tool in the immunotherapy of the gastrointestinal carcinoma. The unresponsiveness of the immunotherapy in vitro could be partially explained by the inverse relationship between the expression of MHC class I antigen and NK cell activity.
저 자   정두현(Doo Hyun Chung),배영미(Young Mi Bae),박재갑(Jae Gahb Park),박성회(Seong Hoe Park),김용일(Yong Il Kim),이상국(Sang Kook Lee)